![]() C max values exhibited a similar dose-dependent increase trend in plasma and tissues except in liver, but other PK parameters had no apparent dose-dependence. ![]() time curve from 0 to 96 h (AUC 0–96) values were considerably increased in gill, kidney, muscle and skin, and plasma, except in liver. As the increase of oral dose from 10 to 40 mg/kg, the area under the concentration vs. The minimum inhibitory concentration of DC against E. ![]() This study aimed to examine the pharmacokinetics of doxycycline (DC) in yellow catfish ( Pelteobagrus fulvidraco) and to calculate related pharmacokinetic–pharmacodynamic (PK/PD) parameters of DC against Edwardsiella ictaluri.
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